{
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  "@type": "article",
  "@id": "https://anchorfact.org/kb/ai-protein-design",
  "headline": "AI Protein Design: RFDiffusion, ProteinMPNN, and the Nobel Revolution",
  "description": "AI protein design has entered the post-AlphaFold era. RFDiffusion generates novel protein structures from scratch; ProteinMPNN designs sequences that fold into desired shapes; the 2024 Nobel Prize validated this revolution — transforming drug discovery and biotechnology.",
  "dateCreated": "2026-05-24T02:49:13.562Z",
  "dateModified": "2026-05-24",
  "author": {
    "@type": "Organization",
    "name": "AnchorFact"
  },
  "publisher": {
    "@type": "Organization",
    "name": "AnchorFact",
    "url": "https://anchorfact.org"
  },
  "license": "https://creativecommons.org/licenses/by/4.0/",
  "anchorfact:confidence": "high",
  "anchorfact:generationMethod": "ai_assisted",
  "citation": [
    {
      "@type": "CreativeWork",
      "name": "De novo design of protein structure and function with RFdiffusion",
      "sameAs": "https://www.nature.com/articles/s41586-023-06415-8"
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    {
      "@type": "CreativeWork",
      "name": "Robust deep learning–based protein sequence design using ProteinMPNN",
      "sameAs": "https://www.science.org/doi/10.1126/science.add2187"
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