Protein Structure Prediction: AlphaFold, RoseTTAFold, and AI-Driven Structural Biology

Status: public · Confidence: medium (0.8) · Basis: verified_sources

## TL;DR
Protein Structure Prediction: AlphaFold, RoseTTAFold, and AI-Driven Structural Biology: Protein structure prediction estimates three-dimensional protein structure from amino-acid sequence or related biological information.

## Core Explanation
AI structure prediction advanced sharply with deep learning systems evaluated in CASP. Strong public claims should distinguish structure prediction from experimental structure determination and from downstream functional validation.

## Further Reading

- [Highly accurate protein structure prediction with AlphaFold](https://www.nature.com/articles/s41586-021-03819-2)
- [Accurate prediction of protein structures and interactions using a three-track neural network](https://www.science.org/doi/10.1126/science.abj8754)
- [Assessment of protein structure prediction in CASP14](https://doi.org/10.1002/prot.26237)